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1. (WO2017062495) METHOD OF TREATING MEDULLOBLASTOMA WITH AN EZH2 INHIBITOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/062495 International Application No.: PCT/US2016/055554
Publication Date: 13.04.2017 International Filing Date: 05.10.2016
IPC:
C07D 405/14 (2006.01) ,C07D 211/86 (2006.01) ,C07D 405/12 (2006.01)
Applicants: EPIZYME, INC.[US/US]; 400 Technology Square 4th Floor Cambridge, MA 02139, US
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE[US/US]; 1800 Grant Street 8th Floor Denver, CO 80203, US
Inventors: KEILHACK, Heike; US
WATERS, Nigel, J.; US
VIBHAKAR, Rajeev; US
Agent: ERLACHER, Heidi, A.; US
OUYANG, Lian; US
Priority Data:
62/238,07406.10.2015US
62/299,31224.02.2016US
Title (EN) METHOD OF TREATING MEDULLOBLASTOMA WITH AN EZH2 INHIBITOR
(FR) PROCÉDÉ DE TRAITEMENT D'UN MÉDULLOBLASTOME AVEC UN INHIBITEUR D'EZH2
Abstract: front page image
(EN) The disclosure provides a method of treating a medulloblastoma in a subject in need thereof comprising administering to the subject a therapeutically-effective amount of an enhancer of a zeste homolog 2 (EZH2) inhibitor. In a preferred embodiment of this method, the subject is pediatric and the EZH2 inhibitor is Tazemetostat.
(FR) La présente invention concerne un procédé de traitement d'un médulloblastome chez un sujet le nécessitant, comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un inhibiteur d'activateur d'homologue de zeste 2 (EZH2). Dans un mode de réalisation préféré de ce procédé, le sujet est pédiatrique et l'inhibiteur d'EZH2 est le tazemetostat.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)