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1. (WO2017062456) BIOMARKERS RELATED TO INTERLEUKIN-33 (IL-33)-MEDIATED DISEASES AND USES THEREOF

Pub. No.:    WO/2017/062456    International Application No.:    PCT/US2016/055502
Publication Date: Fri Apr 14 01:59:59 CEST 2017 International Filing Date: Thu Oct 06 01:59:59 CEST 2016
IPC: C07K 16/24
C07K 14/715
G01N 33/50
Applicants: REGENERON PHARMACEUTICALS, INC.
Inventors: ORENGO, Jamie M.
ALLINNE, Jeanne
FURY, Wen
BAI, Yu
Title: BIOMARKERS RELATED TO INTERLEUKIN-33 (IL-33)-MEDIATED DISEASES AND USES THEREOF
Abstract:
The present invention relates to the identification of certain biomarkers for use in identifying patients who have, or are likely to develop an IL-33 mediated disease or disorder and who are more likely to respond to therapy with an IL-33 antagonist. The invention also relates to methods of treatment of an IL-33-mediated disease or disorder in a patient by administering an IL-33 antagonist to the patient in need thereof and monitoring the effectiveness of therapy using the biomarkers described herein. Also provided are methods for decreasing the level of at least one biomarker in a subject suffering from an IL-33-mediated disease or disorder, and methods for treating such diseases or disorders according to the expression levels of one or more biomarkers. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-33 antagonist.