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1. (WO2017062426) METHODS AND COMPOSITIONS FOR TREATMENT OF METASTATIC AND REFRACTORY CANCERS AND TUMORS

Pub. No.:    WO/2017/062426    International Application No.:    PCT/US2016/055458
Publication Date: Fri Apr 14 01:59:59 CEST 2017 International Filing Date: Thu Oct 06 01:59:59 CEST 2016
IPC: A61K 31/505
A61K 38/20
A61P 35/04
A61P 37/04
C12N 5/0783
Applicants: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
Inventors: CONEJO-GARCIA, Jose, R.
ALLEGREZZA, Michael
Title: METHODS AND COMPOSITIONS FOR TREATMENT OF METASTATIC AND REFRACTORY CANCERS AND TUMORS
Abstract:
A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule that induces T cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the MEK/MAPK pathway and the T cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo. Compositions and kits including these components are also provided.