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1. (WO2017062354) COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGY AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/062354    International Application No.:    PCT/US2016/055316
Publication Date: 13.04.2017 International Filing Date: 04.10.2016
IPC:
A61K 31/41 (2006.01), A61K 31/435 (2006.01), A61P 35/00 (2006.01), A61P 31/00 (2006.01), A61P 37/00 (2006.01)
Applicants: CALITHERA BIOSCIENCES, INC. [US/US]; 343 Oyster Point Blvd., Suite 200 South San Francisco, CA 94080 (US)
Inventors: MOLINEAUX, Susan, M.; (US).
GROSS, Matthew, I; (US).
BROMLEY, Susan, D.; (US).
PARLATI, Francesco; (US).
BENNETT, Mark, K.; (US)
Agent: HALSTEAD, David, P.; (US).
ABELLEIRA, Susan, M.; (US).
AKHEIZER, Alexander; (US).
BLOUNT, Jennifer, V.; (US).
CHOI, Philip, S.; (US)
Priority Data:
62/323,179 15.04.2016 US
62/237,287 05.10.2015 US
Title (EN) COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGY AGENTS
(FR) POLYTHÉRAPIE À L'AIDE D'INHIBITEURS DE GLUTAMINASE ET AGENTS IMMUNO-ONCOLOGIQUES
Abstract: front page image
(EN)The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an immuno-oncology therapeutic agent, such as an inhibitor of arginase, CTLA-4, indoleamine 2, 3 -dioxygenase, and/or PD-1/PD-L1.
(FR)L'invention concerne des méthodes de traitement du cancer, de maladies myéloprolifératives, ou de maladies neurologiques ou immunologiques avec une combinaison d'un inhibiteur de glutaminase et d'un agent thérapeutique immuno-oncologique, tel qu'un inhibiteur d'arginase, de CTLA -4, d'indoléamine 2, 3-dioxygénase, et/ou de PD -1/PD-L1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)