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1. (WO2017061816) AMYLOID-FIBER LENGTH-ADJUSTING METHOD USING CUCURBIT[6]URIL
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/061816 International Application No.: PCT/KR2016/011246
Publication Date: 13.04.2017 International Filing Date: 07.10.2016
IPC:
C07K 14/47 (2006.01) ,D01F 4/00 (2006.01) ,C07D 487/22 (2006.01)
Applicants: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION[KR/KR]; 145, Anam-ro Seongbuk-gu Seoul 02841, KR
Inventors: KIM, Hugh Inkon; KR
CHOI, Tae Su; KR
Agent: JUNG, Eun Youl; KR
Priority Data:
10-2015-014116007.10.2015KR
Title (EN) AMYLOID-FIBER LENGTH-ADJUSTING METHOD USING CUCURBIT[6]URIL
(FR) PROCÉDÉ D'AJUSTEMENT DE LA LONGUEUR DES FIBRES AMYLOÏDES À L'AIDE DE CUCURBIT[6]URILE
(KO) 쿠커비투릴[6]을 이용한 아밀로이드 섬유의 길이 조절 방법
Abstract: front page image
(EN) The present invention relates to an amyloid-fiber length-adjusting method using cucurbit[6]uril, and more specifically relates to an amyloid-fiber length-adjusting method wherein, during a fibrillization reaction of amyloid protein dissolved in a formic acid solvent, the length of the amyloid fibres is adjusted by controlling the amyloid fibrillization process by using cucurbit[6]uril. When implementing the amyloid fibrillization reaction of amyloid protein according to the present invention, the length of the amyloid fibre can be adjusted by adjusting the concentrations and the stirring rate of the cucurbit[6]uril and formic acid solvent, and the inherent functionality of the amyloid fibre can be optimised by providing amyloid fibres having uniform length and size. Also, the formation of amyloid fibre can be efficiently induced by suppressing the formation of the amorphous aggregate by-product produced in the process of making the amyloid fibre.
(FR) La présente invention concerne un procédé d'ajustement de la longueur des fibres amyloïdes à l'aide de cucurbit[6]urile et concerne plus spécifiquement un procédé d'ajustement de la longueur des fibres amyloïdes dans lequel, au cours d'une réaction de formation de fibrilles de la protéine amyloïde dissoute dans un solvant d'acide formique, la longueur des fibres amyloïdes est ajustée par régulation du procédé de la formation de fibrilles amyloïdes à l'aide de cucurbit[6]urile. Lors de la mise en oeuvre de la réaction de formation de fibrilles amyloïdes de protéine amyloïde selon la présente invention, la longueur de la fibre amyloïde peut être ajustée par ajustement de la concentration et de la vitesse d'agitation du cucurbit[6]urile et d'un solvant d'acide formique et la fonctionnalité inhérente de la fibre amyloïde peut être optimisée par l'obtention de fibres amyloïdes présentant une longueur et une taille uniformes. En outre, la formation de fibre amyloïde peut être induite efficacement par la suppression de la formation du sous-produit sous forme d'agrégat amorphe obtenu dans le procédé de fabrication de la fibre amyloïde.
(KO) 본 발명은 쿠커비투릴[6]을 이용한 아밀로이드 섬유의 길이 조절 방법에 관한 것으로, 더욱 상세하게는 포름산 용매에 용해된 아밀로이드성 단백질의 섬유화 반응 시 쿠커비투릴[6]를 이용하여 아밀로이드 섬유화 과정을 제어함으로써 아밀로이드 섬유의 길이를 조절하는 방법에 관한 것이다. 본 발명에 따르면 아밀로이드성 단백질의 아밀로이드 섬유화 반응 수행시 쿠커비투릴[6], 포름산 용매의 농도 및 교반 속도 조절을 통해 아밀로이드 섬유의 길이를 조절할 수 있으며, 균일한 길이와 크기를 가진 아밀로이드 섬유를 제공함으로써 아밀로이드 섬유의 고유 기능성을 최적화할 수 있다. 또한, 아밀로이드 섬유의 생성과정에서 발생하는 부산물인 비정형 응집체의 형성을 억제함으로써 아밀로이드 섬유의 형성을 효율적으로 유도할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)