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1. (WO2017061602) ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO CD147 MOLECULE, AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/061602 International Application No.: PCT/JP2016/079960
Publication Date: 13.04.2017 International Filing Date: 07.10.2016
IPC:
C07K 16/30 (2006.01) ,A61K 39/395 (2006.01) ,A61K 51/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01) ,C07K 16/28 (2006.01) ,C12N 15/00 (2006.01) ,C12N 15/09 (2006.01)
Applicants: PERSEUS PROTEOMICS INC.[JP/JP]; Park Bldg., 7-6, Komaba 4-chome, Meguro-ku, Tokyo 1530041, JP
Inventors: KUROSAWA, Yoshikazu; JP
HOSOMI, Naoki; JP
NOMURA, Fumiko; JP
KOUDA, Katsushi; JP
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013, JP
Priority Data:
2015-20069109.10.2015JP
Title (EN) ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO CD147 MOLECULE, AND USE THEREOF
(FR) ANTICORPS APTE À SE LIER SPÉCIFIQUEMENT À LA MOLÉCULE CD147, ET SON UTILISATION
(JA) CD147分子に特異的に結合する抗体およびその利用
Abstract:
(EN) Provided are a monoclonal antibody capable of specifically binding to human CD147, and a use thereof for treatment against various types of cancer characterized by CD147 expression. The monoclonal antibody against human CD147 or a fragment containing an antigen-binding region thereof has properties a-c, namely, a. reacting against a cancer cell strain which expresses human CD147, b. reacting against a cell strain which expresses cynomolgus monkey CD147, and c. exhibiting in vivo anti-tumor activity against cancer cells which express human CD147.
(FR) L’invention concerne un anticorps monoclonal apte à se lier spécifiquement à une CD147 humaine, et son utilisation dans le traitement contre de nombreux types de cancers caractérisés par l’expression de CD147. L’anticorps monoclonal contre la CD147 humaine ou un fragment contenant une région de liaison à l’antigène de cette dernière présente les propriétés de a à c, à savoir : a. la réaction contre une souche de cellule cancéreuse qui exprime la CD147 humaine, b. la réaction contre une souche cellulaire qui exprime la CD147 du macaque de Buffon, et c. la manifestation d’une activité anti-tumorale in vivo contre des cellules cancéreuses qui expriment la CD147 humaine.
(JA) ヒトCD147に特異的に結合するモノクローナル抗体の提供、CD147発現を特徴づけられる多彩な癌種に対する治療への利用。 次のa~cの性質を有する、ヒトCD147に対するモノクローナル抗体またはその抗原結合領域を含む断片。 a.ヒトCD147発現がん細胞株に対して反応する、 b.カニクイザルCD147発現細胞株に対して反応する、 c.ヒトCD147発現がん細胞に対してin vivoで抗腫瘍活性を示す。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)