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1. (WO2017060925) NOVEL PIPECOLIC ACID CO-CRYSTALS OF DAPAGLIFLOZIN AND PROCESS FOR THE PREPARATION THEREOF
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Pub. No.: WO/2017/060925 International Application No.: PCT/IN2016/050345
Publication Date: 13.04.2017 International Filing Date: 08.10.2016
IPC:
C07H 7/04 (2006.01)
Applicants: HARMAN FINOCHEM LIMITED[IN/IN]; 107, Vinay Bhavya Complex 159 –A, C.S.T. Road, Kalina, Mumbai, Maharashtra 400098, IN
Inventors: KADAM, Vijay Trimbak; IN
SAIKRISHNA, .; IN
SANSARE, Ajit Balasaheb; IN
MINHAS, Harpreet Singh; IN
MINHAS, Gurpreet Singh; IN
Agent: P., Aruna Sree; IN
Priority Data:
3848/MUM/201509.10.2015IN
Title (EN) NOVEL PIPECOLIC ACID CO-CRYSTALS OF DAPAGLIFLOZIN AND PROCESS FOR THE PREPARATION THEREOF
(FR) NOUVEAU CO-CRISTAUX D'ACIDE PIPÉCOLIQUE DE DAPAGLIFLOZINE ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract:
(EN) The present invention discloses the process for preparation of (2S,3R,4R,5S,6R)- 2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran- 3,4,5-trioland its amorphous form. The invention further discloses novelco- crystals of dapagliflozin,and process for preparation thereof. The invention further discloses novel intermediateAcetic acid 4,5-diacetoxy-6-acetoxymethyl-2-R1-2- [4-chloro-3-(4-ethoxy-benzyl)-phenyl]-tetrahydro-pyran-3-yl ester, wherein R1 is allyl or 2-prop-2ynyl useful for preparation 2-R1-2-[4-Chloro-3-(4-ethoxy- benzyl)-phenyl]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol.
(FR) La présente invention concerne un procédé de préparation de (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-éthoxybenzyl)phényl]-6-(hydroxyméthyl)tétrahydro-2H-pyrane-3,4,5-triol et de sa forme amorphe. De nouveaux co-cristaux de dapagliflozine, et leur procédé de préparation, sont en outre décrits. En outre, l'invention concerne de nouveaux acide intermediateAcetic 4,5-diacétoxy-6-acétoxyméthyl-2-R1-2-[4-chloro-3-(4-éthoxy-benzyl) -phényl]-tétrahydro-pyran-3-yl ester, dans lequel R1 est un groupe allyle ou 2-prop-2-ynyl utiles pour la préparation de 2-R1-2-[4-chloro-3-(4-éthoxy-benzyl) -phényl]-6-hydroxyméthyl-tétrahydro-pyran -3,4,5-triol.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)