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1. (WO2017060880) POTENTIATOR-CORRECTOR COMBINATIONS USEFUL IN THE TREATMENT OF CYSTIC FIBROSIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/060880 International Application No.: PCT/IB2016/056036
Publication Date: 13.04.2017 International Filing Date: 07.10.2016
IPC:
A61K 31/00 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: ABBVIE S.À.R.L.[LU/LU]; 26 Boulevard Royal L-2449 Luxembourg, LU
GALAPAGOS NV[BE/BE]; Generaal De Wittelaan L11/A3 2800 Mechelen, BE
Inventors: CONRATH, Katja E.; BE
ROWE, Steven M.; US
Agent: MODIANO, Micaela, Nadia; MODIANO JOSIF PISANTY & STAUB Thierschstrasse 11 80538 München, DE
Priority Data:
62/239,66709.10.2015US
Title (EN) POTENTIATOR-CORRECTOR COMBINATIONS USEFUL IN THE TREATMENT OF CYSTIC FIBROSIS
(FR) COMBINAISONS POTENTIALISATEUR-CORRECTEUR UTILES DANS LE TRAITEMENT DE LA FIBROSE KYSTIQUE
Abstract:
(EN) A combination therapy including a modulator of the function (potentiator) of cystic fibrosis transmembrane conductance regulator (CFTR) protein, and one or two modulator(s) of the cellular processing and/or localization molecule (correctors) is provided in a method for treating cystic fibrosis in a subject having a mutation located between the amino acid residues 1164-1480 of full length wild-type CFTR.
(FR) La présente invention concerne une polythérapie comprenant un modulateur de la fonction (potentialisateur) de la protéine régulatrice de conductance transmembranaire de la fibrose kystique (CFTR), et un ou deux modulateurs de la molécule de localisation et/ou de traitement cellulaire (correcteurs), dans le cadre d'une méthode de traitement de la fibrose kystique chez un sujet présentant une mutation située entre les résidus d'acides aminés 1164-1480 de CFTR de type sauvage de pleine longueur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)