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1. (WO2017060874) N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/060874    International Application No.:    PCT/IB2016/056029
Publication Date: 13.04.2017 International Filing Date: 07.10.2016
IPC:
C07D 471/04 (2006.01), A61K 31/437 (2006.01), A61P 11/12 (2006.01), C07D 519/00 (2006.01)
Applicants: ABBVIE S.Á.R.L [LU/LU]; 26 Boulevard Royal L-2449 Luxembourg (LU).
GALAPAGOS NV [BE/BE]; Generaal de Wittelaan, L11/A3 2800 Mechelen (BE)
Inventors: AKKARI, Rhalid; (FR).
ALVEY, Luke Jonathan; (FR).
BOCK, Xavier Marie; (FR).
BROWN, Brian S.; (US).
CLAES, Pieter Isabelle Roger; (BE).
COWART, Marlon D.; (US).
DE LEMOS, Elsa; (FR).
DESROY, Nicolas; (FR).
DUTHION, Béranger; (FR).
GFESSER, Gregory A.; (US).
GOSMINI, Romain Luc Marie; (FR).
HOUSSEMAN, Christopher Gaëtan; (FR).
JANSEN, Koen Karel; (BE).
JI, Jianguo; (US).
KYM, Philip R.; (US).
LEFRANCOIS, Jean-Michel; (FR).
MAMMOLITI, Oscar; (BE).
MENET, Christel Jeanne Marie; (BE).
MERAYO, Nuria Merayo; (FR).
NEWSOME, Gregory John Robert; (FR).
PALISSE, Adeline Marie Elise; (FR).
PATEL, Sachin V.; (US).
PIZZONERO, Mathieu Rafaël; (FR).
SHRESTHA, Anurupa; (US).
SWIFT, Elizabeth C.; (US).
VAN DER PLAS, Steven Emiel; (BE).
WANG, Xueqing; (US).
DE BLIECK, Ann; (BE)
Agent: MODIANO, Micaela, Nadia; MODIANO JOSIF PISANTY & STAUB Thierschstrasse 11 80538 München (DE)
Priority Data:
62/239,647 09.10.2015 US
62/309,794 17.03.2016 US
Title (EN) N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE
(FR) PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES N-SULFONYLÉS ET LEUR PROCÉDÉ D'UTILISATION
Abstract: front page image
(EN)The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
(FR)La présente invention concerne des composés de formule (I), (I) où R1, R2, R3, R4, R5, et R6 ont l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles à titre d'agents dans le traitement des maladies et des affections médiées et modulées par le CFTR, comprenant la mucoviscidose, le syndrome de Sjögren, l'insuffisance pancréatique, la bronchopneumopathie chronique obstructive et les maladies des voies respiratoires chroniques obstructives. Des compositions pharmaceutiques comprenant un ou plusieurs composés de formule (I) sont en outre décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)