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1. (WO2017060431) SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/060431 International Application No.: PCT/EP2016/074008
Publication Date: 13.04.2017 International Filing Date: 07.10.2016
IPC:
C07D 471/22 (2006.01) ,C07D 487/22 (2006.01) ,A61K 31/438 (2006.01) ,A61P 35/00 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH[DE/DE]; Binger Strasse 173 55216 Ingelheim Am Rhein, DE
Inventors: GOLLNER, Andreas; DE
BROEKER, Joachim; DE
KERRES, Nina; DE
KOFINK, Christiane; DE
RAMHARTER, Juergen; DE
WEINSTABL, Harald; DE
GILLE, Annika; DE
GOEPPER, Stefan; DE
HENRY, Manuel; DE
HUCHLER, Guenther; DE
Agent: SIMON, ET AL., Elke; DE
WEIK, Steffen; DE
Priority Data:
15189210.609.10.2015EP
Title (EN) SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS
(FR) COMPOSÉS DE SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE ET LEURS DÉRIVÉS À TITRE D'INHIBITEURS DE MDM2-P53
Abstract: front page image
(EN) The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, R7, A, D, E, F, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.
(FR) La présente invention concerne des composés de formule (I) dans laquelle les groupes R1 à R4, R7, A, D, E, F, V, W, X, Y, n, r et q sont définis dans la revendication 1, leur utilisation à titre d'inhibiteurs de l'interaction MDM2-p53, des compositions pharmaceutiques les contenant, leur utilisation à titre de médicaments, notamment à titre d'agents destinés à traiter et/ou à prévenir les maladies oncologiques, et les intermédiaires formés au cours de leur synthèse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)