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1. (WO2017060326) PROCESS FOR THE PREPARATION OF (E)-3-(4-((E)-2-(2-CHLORO-4-FLUOROPHENYL)-1-(1H-INDAZOL-5-YL)BUT-1-EN-1-YL)PHENYL)ACRYLIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/060326    International Application No.:    PCT/EP2016/073831
Publication Date: 13.04.2017 International Filing Date: 06.10.2016
IPC:
C07D 231/56 (2006.01), C07C 69/612 (2006.01), C07D 405/04 (2006.01), C07F 5/04 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (US only)
Inventors: BACHMANN, Stephan; (CH).
FANTASIA, Serena Maria; (CH).
GOSSELIN, Francis; (US).
HAN, Chong; (US).
HILDBRAND, Stefan; (CH).
HUMPHRIES, Theresa; (US).
JENNY, Christian; (CH).
LIM, Ngiap-Kie; (US).
MCCLORY, Andrew; (US).
MOESSNER, Christian; (CH).
REGE, Pankaj D.; (CH).
SAVAGE, Scott; (US).
ZHANG, Haiming; (US)
Agent: HAEFELE RACIN, Thomas; (CH)
Priority Data:
62/238,230 07.10.2015 US
Title (EN) PROCESS FOR THE PREPARATION OF (E)-3-(4-((E)-2-(2-CHLORO-4-FLUOROPHENYL)-1-(1H-INDAZOL-5-YL)BUT-1-EN-1-YL)PHENYL)ACRYLIC ACID
(FR) PROCÉDÉ POUR LA PRÉPARATION D'ACIDE (E)-3-(4-((E)-2-(2-CHLORO-4-FLUOROPHÉNYL)-1-(1H-INDAZOL-5-YL)BUT-1-ÉN-1-YL)PHÉNYL)ACRYLIQUE
Abstract: front page image
(EN)Processes are described for the preparation of estrogen receptor modulating compound, (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid (I): and salts thereof, and intermediates useful for the preparation of (I).
(FR)L'invention concerne des procédés pour la préparation d'un composé modulant le récepteur d'oestrogène, l'acide (E)-3-(4-((E)-2-(2-chloro-4-fluorophényl)-1-(1H-indazol-5-yl)but-1-én-1-yl)phényl)acrylique (I) : et des sels correspondants et des intermédiaires utiles pour la préparation de (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)