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1. (WO2017060283) SPECIFIC IMMUNODOMINANT PEPTIDE EPITOPES FOR POLYOMAVIRUS VACCINE
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Pub. No.: WO/2017/060283 International Application No.: PCT/EP2016/073760
Publication Date: 13.04.2017 International Filing Date: 05.10.2016
IPC:
A61K 38/16 (2006.01) ,A61K 39/12 (2006.01) ,C07K 14/025 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
025
Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
Applicants:
UNIVERSITÄT BASEL [CH/CH]; Vizerektorat Forschung Petersgraben 35 4001 Basel, CH
Inventors:
HIRSCH, Hans H.; CH
LEBOEUF, Céline; FR
Agent:
SPERRLE, Martin; CH
Priority Data:
15188578.706.10.2015EP
Title (EN) SPECIFIC IMMUNODOMINANT PEPTIDE EPITOPES FOR POLYOMAVIRUS VACCINE
(FR) ÉPITOPES PEPTIDIQUES IMMUNODOMINANTS SPÉCIFIQUES POUR VACCIN CONTRE POLYOMAVIRUS
Abstract:
(EN) The invention relates to immunodominant peptide epitopes of BK, JC and MC polyomavirus; carriers, such as virus-like particles, virosomes or nanoparticles, comprising such peptide epitopes; vaccines against polyomavirus infection comprising such peptide epitopes and/or loaded carriers; and nucleic acids encoding these peptide epitopes. The invention further relates to diagnostic and therapeutic methods using these peptide epitopes in polyomavirus-associated diseases such as nephropathy or hemorrhagic cystitis of importance for transplant recipients.
(FR) La présente invention concerne des épitopes de peptide immunodominants de polyomavirus BK, JC et MC ; des supports, tels que des particules pseudovirales, des virosomes ou des nanoparticules, comprenant de tels épitopes peptidiques ; des vaccins contre une infection à polyomavirus comprenant de tels épitopes peptidiques et/ou supports chargés ; et des acides nucléiques codant pour ces épitopes peptidiques. L’invention concerne en outre des procédés diagnostiques et thérapeutiques utilisant ces épitopes peptidiques dans des maladies associées à un polyomavirus telles qu’une néphropathie ou une cystite hémorragique d’importance pour les receveurs de greffe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)