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1. WO2017059902 - 3' UTR SEQUENCES FOR STABILIZATION OF RNA

Publication Number WO/2017/059902
Publication Date 13.04.2017
International Application No. PCT/EP2015/073180
International Filing Date 07.10.2015
IPC
C12N 15/67 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
CPC
A47B 13/02
AHUMAN NECESSITIES
47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
BTABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
13Details of tables or desks
02Underframes
A47B 2003/006
AHUMAN NECESSITIES
47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
BTABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
3Folding or stowable tables
002with foldable underframe
006having X/Y-crossed legs rotating around a central vertical axis
A47B 2200/0018
AHUMAN NECESSITIES
47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
BTABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
2200General construction of tables or desks
0011Underframes
0017Nodal leg assembly for table
0018in two parts
A47B 3/002
AHUMAN NECESSITIES
47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
BTABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
3Folding or stowable tables
002with foldable underframe
A47B 33/00
AHUMAN NECESSITIES
47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
BTABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
33Kitchen or dish-washing tables
A47B 43/00
AHUMAN NECESSITIES
47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
BTABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
43Cabinets, racks or shelf units, characterised by features enabling folding of the cabinet or the like
Applicants
  • BIONTECH RNA PHARMACEUTICALS GMBH [DE]/[DE]
  • TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH [DE]/[DE]
Inventors
  • ORLANDINI VON NIESSEN, Alexandra
  • FESSER, Stephanie
  • VALLAZZA, Britta
  • BEISSERT, Tim
  • KUHN, Andreas
  • SAHIN, Ugur
Agents
  • SCHNAPPAUF, Georg
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3' UTR SEQUENCES FOR STABILIZATION OF RNA
(FR) SÉQUENCES UTR 3' PERMETTANT LA STABILISATION D'ARN
Abstract
(EN)
The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
(FR)
La présente invention concerne la stabilisation d'ARN, en particulier d'ARNm, et une augmentation de la traduction de l'ARNm. La présente invention concerne plus particulièrement une modification de l'ARN, en particulier de l'ARN transcrit in vitro, ce qui permet d'obtenir une stabilité de transcription et/ou une efficacité de traduction accrue. Selon l'invention, il a été démontré que certaines séquences dans la région non traduite 3'-(UTR) d'une molécule d'ARN améliorent la stabilité et l'efficacité de la traduction.
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