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1. (WO2017059786) A NEW TYPE POLYPEPTIDE TARGETING TUMOURS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/059786    International Application No.:    PCT/CN2016/100989
Publication Date: 13.04.2017 International Filing Date: 30.09.2016
IPC:
C07K 7/50 (2006.01), A61K 47/42 (2017.01), A61P 35/00 (2006.01)
Applicants: SICHUAN UNIVERSITY [CN/CN]; No.24 South Section 1, Yihuan Road, Wuhou District Chengdu, Sichuan 610065 (CN).
YAOPHARMA CO., LTD. [CN/CN]; 100 Xingguang Avenue, Renhe Town, Yubei District Chongqing 401121 (CN)
Inventors: ZHANG, Zhirong; (CN).
GONG, Tao; (CN).
ZHANG, Yan; (CN).
SONG, Xu; (CN).
CHEN, Tijia; (CN).
FU, Yao; (CN).
SUN, Xun; (CN).
BAI, Xiaoqing; (CN).
ZHANG, Bei; (CN)
Agent: UNITALEN ATTORNEYS AT LAW; 7th Floor, Scitech Place No.22, Jian Guo Men Wai Ave. Chao Yang District Beijing 100004 (CN)
Priority Data:
201510650649.2 10.10.2015 CN
Title (EN) A NEW TYPE POLYPEPTIDE TARGETING TUMOURS
(FR) POLYPEPTIDE DE NOUVEAU TYPE CIBLANT LES TUMEURS
(ZH) 一种肿瘤靶向的新型多肽
Abstract: front page image
(EN)Provided is a nRGD polypeptide formed by connecting alanine-alanine-asparagine (AAN) and a polypeptide containing arginine-glycine-aspartic acid (RGD), wherein the nRGD polypeptide can target tumour vessels, tumour cells and tumour-associated macrophages, and mediate the targeted delivery of tumours.
(FR)L'invention concerne un polypeptide nRGD formée par liaison d'alanine-alanine-asparagine (AAN) et un polypeptide contenant de l'arginine-glycine-acide aspartique (RGD), le polypeptide nRGD pouvant cibler des vaisseaux tumoraux, des cellules tumorales et des macrophages associés à une tumeur, et assurant la médiation de l'administration ciblée de tumeurs.
(ZH)提供一种由丙氨酸-丙氨酸-天冬酰胺(AAN)和含精氨酸-甘氨酸-天冬氨酸(RGD)多肽连接而成的多肽nRGD;所述多肽nRGD可靶向肿瘤血管、肿瘤细胞和肿瘤相关巨噬细胞,介导肿瘤靶向传递。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)