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1. (WO2017059427) METHODS FOR MONITORING AND DETERMINING THE PROGNOSIS OF STROKES, PERIPHERAL VASCULAR DISEASE, SHOCK, AND SICKLE CELL DISEASE AND ITS COMPLICATIONS
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Pub. No.: WO/2017/059427 International Application No.: PCT/US2016/055171
Publication Date: 06.04.2017 International Filing Date: 03.10.2016
IPC:
A61K 31/138 (2006.01) ,A61K 31/325 (2006.01) ,A61K 45/06 (2006.01) ,A61K 47/50 (2017.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
138
Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
325
Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
[IPC code unknown for A61K 47/50]
Applicants: CHILDREN'S NATIONAL MEDICAL CENTER[US/US]; 111 Michigan Avenue, N.W. Washington, DC 20010, US
Inventors: QUEZADO, Zenaide, M.n.; US
ALMEIDA, Luis, E.; US
SPORNICK, Nicholas, A.; US
Agent: LOVE, James; US
MASON, J. Derek; US
Priority Data:
62/236,40002.10.2015US
Title (EN) METHODS FOR MONITORING AND DETERMINING THE PROGNOSIS OF STROKES, PERIPHERAL VASCULAR DISEASE, SHOCK, AND SICKLE CELL DISEASE AND ITS COMPLICATIONS
(FR) PROCÉDÉS DE CONTRÔLE ET DE DÉTERMINATION DU PRONOSTIC D'AVC, DE MALADIE VASCULAIRE PÉRIPHÉRIQUE, DE CHOC ET DE DRÉPANOCYTOSE ET DE SES COMPLICATIONS
Abstract:
(EN) This invention provides a method for the diagnosis and monitormg of Sickle Cell Disease and other conditions that involve the occlusion of blood vessels by detecting alterations in the level of activated caspases, especially a pi 7 fragment of caspase 3 in blood plasma. Methods for treating subjects identified as having elevated pi 7 levels are also described.
(FR) La présente invention concerne un procédé pour le diagnostic et le contrôle de la drépanocytose et d'autres états qui entraînent l'occlusion des vaisseaux sanguins par la détection d'altérations du niveau de caspases activées, en particulier un fragment pi 7 de caspase 3 dans le plasma sanguin. L'invention concerne également des procédés pour traiter des sujets identifiés comme ayant des niveaux élevés de pi 7.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)