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1. (WO2017059411) INHIBITORS OF MENAQUINONE BIOSYNTHESIS

Pub. No.:    WO/2017/059411    International Application No.:    PCT/US2016/055136
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Tue Oct 04 01:59:59 CEST 2016
IPC: C08G 77/38
C08G 77/20
G02B 1/04
Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors: TAN, Derek, Shieh
EVANS, Christopher, E.
SHARMA, Indrajeet
TONGE, Peter, James
MATARLO, Joe, S.
Title: INHIBITORS OF MENAQUINONE BIOSYNTHESIS
Abstract:
Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin- resistant Staphylococcus aureus).