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1. (WO2017059397) LABELING OF ANTIBODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/059397 International Application No.: PCT/US2016/055074
Publication Date: 06.04.2017 International Filing Date: 01.10.2016
IPC:
C07K 16/28 (2006.01) ,C07K 16/46 (2006.01) ,G01N 33/58 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH[US/US]; Nine Cambridge Center Cambridge, MA 02142, US
THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUDETTS GENERAL HOSPITAL[US/US]; 55 Fruit Street Boston, MA 02114, US
Inventors: RASHIDIAN, Mohammad; US
PLOEGH, Hidde L.; US
VASDEV, Neil; US
LIANG, Huan Steven; US
Agent: HEBERT, Alan M.; US
Priority Data:
62/236,11701.10.2015US
Title (EN) LABELING OF ANTIBODIES
(FR) MARQUAGE D'ANTICORPS
Abstract:
(EN) Provided herein are methods for producing site specific PEG modifications to single domain antibodies (e.g., VHHs). Methods for producing site- specific ally conjugated bivalent single domain antibodies (e.g., VHHs) are also provided. Methods for labeling (e.g., with a fluorophore or radionuclide) site-specifically PEGylated single domain antibodies and site- specifically conjugated bivalent single domain antibodies are also provided.
(FR) L'invention concerne des procédés d'introduction de modifications PEG spécifiques de site dans des anticorps à domaine unique (p. ex., VHH). L'invention concerne également des procédés de production d'anticorps à domaine unique (p. ex., VHH) bivalents conjugués spécifiques de site. Des procédés de marquage (p. ex., à l'aide d'un fluorophore ou d'un radionucléide) d'anticorps à domaine unique PEGylés spécifiques de site, et d'anticorps à domaine unique bivalents conjugués spécifiques de site sont en outre décrits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)