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1. (WO2017059313) COMPREHENSIVE IN VITRO REPORTING OF CLEAVAGE EVENTS BY SEQUENCING (CIRCLE-SEQ)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/059313    International Application No.:    PCT/US2016/054912
Publication Date: 06.04.2017 International Filing Date: 30.09.2016
IPC:
C12N 15/10 (2006.01), C12Q 1/68 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, Massachusetts 02114 (US)
Inventors: JOUNG, J. Keith; (US).
TSAI, Shengdar; (US)
Agent: DEYOUNG, Janice Kugler; (US).
FASSE, J. Peter; (US)
Priority Data:
62/235,154 30.09.2015 US
Title (EN) COMPREHENSIVE IN VITRO REPORTING OF CLEAVAGE EVENTS BY SEQUENCING (CIRCLE-SEQ)
(FR) RAPPORT IN VITRO COMPLET D'ÉVÉNEMENTS DE CLIVAGE PAR SÉQUENÇAGE (CIRCLE-SEQ)
Abstract: front page image
(EN)Sensitive, unbiased methods for genome-wide detection of potential CRISPR-Cas9 off-target cleavage sites from cell type-specific genomic DNA samples.
(FR)L'invention concerne des méthodes non biaisées, sensibles, de détection à l'échelle du génome de sites de clivage hors cible de CRISPR-Cas9 potentiels à partir d'échantillons d'ADN génomique spécifique d'un type de cellule.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)