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1. (WO2017059313) COMPREHENSIVE IN VITRO REPORTING OF CLEAVAGE EVENTS BY SEQUENCING (CIRCLE-SEQ)

Pub. No.:    WO/2017/059313    International Application No.:    PCT/US2016/054912
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Sat Oct 01 01:59:59 CEST 2016
IPC: C12N 15/10
C12Q 1/68
Applicants: THE GENERAL HOSPITAL CORPORATION
Inventors: JOUNG, J. Keith
TSAI, Shengdar
Title: COMPREHENSIVE IN VITRO REPORTING OF CLEAVAGE EVENTS BY SEQUENCING (CIRCLE-SEQ)
Abstract:
Sensitive, unbiased methods for genome-wide detection of potential CRISPR-Cas9 off-target cleavage sites from cell type-specific genomic DNA samples.