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1. (WO2017059309) TREATMENT OF ACUTE TRAUMATIC INJURY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/059309    International Application No.:    PCT/US2016/054903
Publication Date: 06.04.2017 International Filing Date: 30.09.2016
IPC:
A61K 45/06 (2006.01), A61K 31/4409 (2006.01), A61P 9/10 (2006.01), A61P 21/00 (2006.01)
Applicants: UNIVERSITY OF ROCHESTER [US/US]; Box OTT 601 Elmwood Avenue Rochester, New York 14642 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
NOBLE, Mark [US/US]; (US) (US only).
PRÖSCHEL, Christoph [US/US]; (US) (US only).
NATOLA, Heather [US/US]; (US) (US only).
TSENG, Kuang-Ching [US/US]; (US) (US only).
YUE, Li [US/US]; (US) (US only).
ELFAR, John C. [US/US]; (US) (US only)
Inventors: NOBLE, Mark; (US).
PRÖSCHEL, Christoph; (US).
NATOLA, Heather; (US).
TSENG, Kuang-Ching; (US).
YUE, Li; (US).
ELFAR, John C.; (US)
Agent: JACKSON BECKFORD, Shirlene; (US).
CURFMAN, Christopher L.; (US)
Priority Data:
62/235,874 01.10.2015 US
Title (EN) TREATMENT OF ACUTE TRAUMATIC INJURY
(FR) TRAITEMENT D'UNE LÉSION TRAUMATIQUE AIGUË
Abstract: front page image
(EN)Compositions and methods of treating a subject with an acute traumatic injury are disclosed. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a potassium channel blocker. The potassium channel blocker can include 4-aminopyridine, a derivative thereof, or a combination thereof. The pharmaceutical composition can be administered with an additional therapeutic agent such as an anticonvulsant. The methods can be used for treating acute traumatic injury to an excitable tissue. The methods can restore at least a portion of lost motor function or sensory function, enhance repair and regeneration of stem or progenitor cells such as to promote neural cell generation, enhance cell survival, reduce scarring, decreases sox9 expression, chondroitin sulfate proteoglycan expression, and other markers of tissue damage, decreases lesion size, decreases oxidative damage, or combinations thereof.
(FR)L'invention concerne des compositions et des méthodes de traitement d'un sujet atteint d'une lésion traumatique aiguë. Les méthodes comprennent l'administration au sujet d'une quantité thérapeutiquement efficace d'une composition pharmaceutique comprenant un bloquant du canal potassique. Le bloquant du canal potassique peut comprendre la 4-aminopyridine, son dérivé, ou leur combinaison. La composition pharmaceutique peut être administrée avec un agent thérapeutique supplémentaire tel qu'un anticonvulsivant. Ces méthodes peuvent être utilisées pour traiter une lésion traumatique aiguë sur un tissu excitable. Ces méthodes permettent de restaurer au moins une partie de la perte de fonction motrice ou de la fonction sensorielle, d'améliorer la réparation et la régénération de cellules souches ou progénitrices de manière à favoriser la génération de cellules neurales, de renforcer la survie cellulaire, de réduire la formation de cicatrices, de diminuer l'expression du sox9, de la protéoglycane de chondroïtine-sulfate et d'autres marqueurs de lésion tissulaire, de diminuer la taille d'une lésion, de diminuer les dommages oxydatifs, ou leurs combinaisons.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)