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1. (WO2017059225) TLR MODULATORS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/059225    International Application No.:    PCT/US2016/054734
Publication Date: 06.04.2017 International Filing Date: 30.09.2016
IPC:
C12N 15/113 (2010.01), A61K 48/00 (2006.01)
Applicants: CELGENE CORPORATION [US/US]; 86 Morris Avenue Summit, NJ 07901 (US) (US only).
CELGENE ALPINE INVESTMENT COMPANY II, LLC; AON House, 30 Woodbourne Avenue Pembroke, HM 08 (BM) (For All Designated States Except US)
Inventors: HORAN, Gerald Scott Barden; (US)
Agent: MARTINEK, Sebastian; (US).
BRUNER, Michael, J.; (US).
RIEGER, Dale, L.; (US).
GEORGE, Nikolaos, C.; (US).
INSOGNA, Anthony, M.; (US)
Priority Data:
62/235,475 30.09.2015 US
62/360,256 08.07.2016 US
Title (EN) TLR MODULATORS AND METHODS OF USE
(FR) MODULATEURS TLR ET MÉTHODES D'UTILISATION ASSOCIÉES
Abstract: front page image
(EN)Described herein are combinations comprising a SMAD7 oligonucleotide and a Toll-like receptor (TLR) modulator. Methods for using such combinations to treat disease conditions, including inflammatory disorders, such as inflammatory bowel disease (IBD), are also provided herein.
(FR)La présente invention concerne des combinaisons comprenant un oligonucléotide SMAD7 et un modulateur du récepteur de type Toll (TLR). L'invention concerne également des procédés d'utilisation de ces combinaisons pour traiter des états pathologiques, y compris les troubles inflammatoires, tels que la maladie intestinale inflammatoire (IBD.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)