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1. (WO2017059204) AZOLYLACRYLOYL DERIVATIVES AS THERAPEUTIC AGENTS FOR SICKLE CELL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/059204    International Application No.:    PCT/US2016/054684
Publication Date: 06.04.2017 International Filing Date: 30.09.2016
IPC:
A01N 65/00 (2009.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 800 East Leigh Street, Suite 3000 Richmond, VA 23298 (US)
Inventors: SAFO, Martin, K.; (US).
ZHANG, Yan; (US).
GHATGE, Mohini; (US).
ABDULMALIK, Osheiza; (US).
OMAR, Abdelsattar, Mansour Ebid; (SA).
EL-ARABY, Moustafa, El-Sayed; (SA)
Agent: WHITHAM, Michael E.; (US).
WHITHAM, Michael, E.; (US).
CURTIS, Marshall, M.; (US).
FIELDS, Whitney, C.; (US)
Priority Data:
62/236,486 02.10.2015 US
Title (EN) AZOLYLACRYLOYL DERIVATIVES AS THERAPEUTIC AGENTS FOR SICKLE CELL DISEASE
(FR) DÉRIVÉS D'AZOLYLACRYLOYLE EN TANT QU'AGENTS THÉRAPEUTIQUES POUR LA DRÉPANOCYTOSE
Abstract: front page image
(EN)Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.
(FR)L'invention concerne des dérivés d'azolylacryloyle avec des propriétés hypoxiques. Les composés ont une formule générale et sont appropriés pour le traitement de la drépanocytose et des maladies à la base de l'hypoxie, par exemple les chocs hémorragiques et traumatiques, les arrêts cardiaques et les chocs cardiogéniques, les lésions cérébrales traumatiques, les cancers, les attaques, les infarctus du myocarde, les ischémies myocardiques, les crises d'occlusion vasculaire, etc.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)