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1. (WO2017059175) COMPOSITIONS FOR AN INJECTABLE, IN SITU FORMING NEUROSCAFFOLD AND METHODS OF USING THE SAME

Pub. No.:    WO/2017/059175    International Application No.:    PCT/US2016/054614
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Sat Oct 01 01:59:59 CEST 2016
IPC: A61L 27/52
A61K 9/10
A61K 9/127
A61K 31/095
A61K 47/30
Applicants: PIXARBIO CORPORATION
Inventors: CRISCIONE, Jason, M.
REYNOLDS, Francis, M.
DAI, Haining
BADER, Rebecca, A.
Title: COMPOSITIONS FOR AN INJECTABLE, IN SITU FORMING NEUROSCAFFOLD AND METHODS OF USING THE SAME
Abstract:
Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.