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1. (WO2017058895) AMYLOID BETA DETECTION BY MASS SPECTROMETRY
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Pub. No.: WO/2017/058895 International Application No.: PCT/US2016/054148
Publication Date: 06.04.2017 International Filing Date: 28.09.2016
IPC:
G01N 33/68 (2006.01) ,B01D 15/26 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
15
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08
Selective adsorption, e.g. chromatography
26
characterised by the separation mechanism
Applicants:
QUEST DIAGNOSTICS INVESTMENTS LLC [US/US]; 3 Giralda Farms Madison, New Jersey 07940, US
Inventors:
TRAN, Diana; US
WEBER, Darren; US
CLARKE, Nigel; US
Agent:
QUEST DIAGNOSTICS INVESTMENTS LLC; 3 Giralda Farms Madison, New Jersey 07940, US
LOMPREY, Jeffrey; US
MEARA, Joseph; US
KALAFUT, Christopher; US
Priority Data:
62/234,02728.09.2015US
62/277,77212.01.2016US
Title (EN) AMYLOID BETA DETECTION BY MASS SPECTROMETRY
(FR) DÉTECTION DE BÊTA-AMYLOÏDE PAR SPECTROMÉTRIE DE MASSE
Abstract:
(EN) Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (Αβ42) to amyloid beta 40 (Αβ40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
(FR) L'invention concerne des procédés de détection ou de quantification de bêta-amyloïde. Dans un aspect particulier, la présente invention concerne des procédés de détection de bêta-amyloïde ou de fragments de celle-ci par spectrométrie de masse. Dans un autre aspect, l'invention concerne des procédés de détermination du rapport de la bêta-amyloïde 42 (Αβ42) à la bêta-amyloïde 40 (Αβ40). Dans un autre aspect, l'invention concerne des méthodes pour le diagnostic ou le pronostic de la maladie d'Alzheimer ou la démence.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)