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1. (WO2017058866) ANTI-TREM2 ANTIBODIES AND USES THEREOF
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Pub. No.: WO/2017/058866 International Application No.: PCT/US2016/054104
Publication Date: 06.04.2017 International Filing Date: 28.09.2016
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
Applicants:
MCLAUGHLIN, Megan [US/US]; US
BROZ, Miranda [US/US]; US
PRECISION IMMUNE, INC. [US/US]; 953 Indiana Street San Francisco, CA 94107, US
Inventors:
MCLAUGHLIN, Megan; US
BROZ, Miranda; US
Agent:
KABLER, Kevin; US
SHUSTER, Michael, J.; US
HURT, Nicholas; US
HUBL, Susan, T.; US
Priority Data:
62/233,80528.09.2015US
62/352,30520.06.2016US
Title (EN) ANTI-TREM2 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-TREM2 ET LEURS UTILISATIONS
Abstract:
(EN) Provided herein are anti-TREM2 antibodies and related methods of making and using anti- TREM2 antibodies. Also provided are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an anti-TREM2 antibody or antigen binding fragment thereof.
(FR) La présente invention concerne des anticorps anti-TREM2 et des procédés associés de fabrication et d'utilisation desdits anticorps anti-TREM2. Des méthodes et des compositions destinées à améliorer une réponse immunitaire et/ou à traiter un état pathologique d'origine immunitaire chez un individu, p. ex., le cancer, comprenant la destruction, l'inactivation, ou l'épuisement des cellules myéloïdes non stimulatrices à l'aide d'un anticorps anti-TREM2 ou d'un fragment de celui-ci se liant à l'antigène sont en outre décrites.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)