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1. (WO2017058850) CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS FOR AUTO- AND ALLO-IMMUNITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/058850 International Application No.: PCT/US2016/054076
Publication Date: 06.04.2017 International Filing Date: 28.09.2016
IPC:
A61K 48/00 (2006.01) ,C12N 15/00 (2006.01) ,C07H 21/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA[US/US]; 600 McNamara Alumni Center 200 Oak Street SE Minneapolis, Minnesota 55455-2020, US
Inventors: BLAZAR, Bruce R.; US
FLYNN, Ryan P.; US
PENNELL, Christopher A.; US
Agent: PARSONS, M. Angela; US
FINN III, J. Patrick; US
Priority Data:
62/233,90828.09.2015US
Title (EN) CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS FOR AUTO- AND ALLO-IMMUNITY
(FR) LYMPHOCYTES T DE TYPE RÉCEPTEUR D'ANTIGÈNE CHIMÉRIQUE (CAR) EN TANT QU'INTERVENTIONS THÉRAPEUTIQUES D'AUTO- ET D'ALLO-IMMUNITÉ
Abstract:
(EN) Provided herein are methods and materials for treating autoimmune diseases and alloimmune diseases. Specifically, provided are a pharmaceutical composition comprising a therapeutically effective amount of a population of modified human T cells, wherein the human T cells are modified to comprise a nucleic acid sequence that encodes a chimeric antigen receptor (CAR) construct, wherein the CAR construct comprises an antigen binding domain, wherein the antigen binding domain is specific for a ligand expressed on B cells, plasma cells or plasmablasts in human patients suffering from an autoimmune disease or an alloimmune disease; and a method of treating an autoimmune or an alloimmune disease in a human patient, the method comprising: administering a pharmaceutical composition.
(FR) La présente invention concerne des procédés et des matériaux permettant de traiter des maladies auto-immunes et des maladies allo-immunes. Elle concerne plus particulièrement une composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'une population de cellules T humaines modifiées, les cellules humaines T étant modifiées pour comprendre une séquence d'acides nucléiques qui code pour une construction de récepteur antigénique chimérique (CAR), la construction CAR comprenant un domaine de liaison d'antigène, ledit domaine de liaison d'antigène étant spécifique pour un ligand exprimé sur les cellules B, les cellules de plasma ou les plasmablastes chez les patients humaines souffrant d'une maladie auto-immune ou allo-immune; et une méthode pour traiter une maladie auto-immune ou allo-immune chez un patient humain, la méthode comprenant l'administration d'une composition pharmaceutique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)