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1. (WO2017058828) METHODS FOR TREATING DISEASES MEDIATED BY ERBB4-POSITIVE PRO-INFLAMMATORY MACROPHAGES
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Pub. No.: WO/2017/058828 International Application No.: PCT/US2016/054027
Publication Date: 06.04.2017 International Filing Date: 27.09.2016
IPC:
A61K 38/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
Applicants:
CHILDREN'S HOSPITAL LOS ANGELES [US/US]; 4650 Sunset Boulevard Los Angeles, California 90027, US
Inventors:
FREY, Mark R.; US
SCHUMACHER, Michael; US
Agent:
VAKHARIA-RAO, Hema; US
BIRKENEDER, Erik J.; US
CHEN, Stephen, W.; US
COSTELLIA, Jeffrey; US
DUKE, Brian T.; US
EISENSTEIN, Ronald, I.; US
GARETTO, Janet, M.; US
GATZ, Robert; US
HUBER, Linda B.; US
KIM, Sean; US
LEVY, Seth D.; US
MATTAN-HUNG, Natalia; US
PROMMER, Peter J.; US
RESNICK, David S.; US
RITCHIE,, David B.; US
SWIATEK, Maria; US
TANG, Wayne L.; US
Priority Data:
62/233,92828.09.2015US
Title (EN) METHODS FOR TREATING DISEASES MEDIATED BY ERBB4-POSITIVE PRO-INFLAMMATORY MACROPHAGES
(FR) MÉTHODES DE TRAITEMENT DE MALADIES À MÉDIATION PAR LES MACROPHAGES PRO-INFLAMMATOIRES POSITIFS À L'ERBB4
Abstract:
(EN) Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.
(FR) La présente invention concerne des méthodes et des compositions pour le traitement d'états pathologiques associés à la présence d'un nombre accru de macrophages pro-inflammatoires positifs à l'ErbB4 chez un patient qui en a besoin. Les méthodes consistent à utiliser un activateur de l'ErbB4 et à administrer une quantité thérapeutiquement efficace de l'activateur au patient. Les compositions comprennent un activateur de l'ErbB4. Dans un mode de réalisation, l'activateur de l'ErbB4 est la Neuréguline-4.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)