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1. (WO2017058753) CHIMERIC ANTIGEN RECEPTOR, REGULATORY CELLS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/058753    International Application No.:    PCT/US2016/053896
Publication Date: 06.04.2017 International Filing Date: 27.09.2016
IPC:
A61K 31/7088 (2006.01), A61K 35/17 (2015.01), A61K 48/00 (2006.01), A61P 37/06 (2006.01), A61P 37/08 (2006.01)
Applicants: TRUSTEES OF DARTMOUTH COLLEGE [US/US]; 11 Rope Ferry Road Hanover, NH 03755 (US)
Inventors: SENTMAN, Charles, L.; (US).
ARELLANO, Benjamine, H.; (US)
Agent: LICATA, Jane, Massey; (US).
TYRRELL, Kathleen, A.; (US)
Priority Data:
62/233,526 28.09.2015 US
Title (EN) CHIMERIC ANTIGEN RECEPTOR, REGULATORY CELLS AND METHODS OF USE
(FR) RÉCEPTEUR D'ANTIGÈNE CHIMÈRE, CELLULES RÉGULATRICES ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)A chimeric antigen receptor including a co-inhibitory receptor signaling domain, as well as a nucleic acid construct and immune cells expressing the same are described. Kits and methods of using the immune cells in the treatment or amelioration of chronic inflammation or immune-mediated autoimmunity are also provided.
(FR)La présente invention concerne un récepteur d'antigène chimère comprenant un domaine de signalisation du récepteur co-inhibiteur, ainsi qu'une construction d'acide nucléique et des cellules immunitaires exprimant ceux-ci. La présente invention concerne également des kits et des procédés d'utilisation des cellules immunitaires dans le traitement ou l'amélioration d'une inflammation chronique ou d'une auto-immunité à médiation immunitaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)