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1. (WO2017058691) PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/058691 International Application No.: PCT/US2016/053652
Publication Date: 06.04.2017 International Filing Date: 26.09.2016
IPC:
C07D 239/70 (2006.01) ,A61K 31/517 (2006.01) ,A61P 25/28 (2006.01) ,C07D 401/10 (2006.01)
Applicants: CHEN, Qinghao[US/US]; US (US)
SCOTT, Jeremy[GB/GB]; GB (US)
KRSKA, Shane, W.[US/US]; US (US)
BAXTER, Carl[GB/GB]; GB (US)
STEWART, Gavin William[GB/GB]; GB (US)
TAN, Lushi[US/US]; US (US)
GIBB, Andrew[GB/GB]; GB (US)
MALIGRES, Peter, E.[US/US]; US (US)
MERCK SHARP & DOHME CORP.[US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
MERCK SHARP & DOHME LIMITED[GB/GB]; Hertford Road Hoddesdon Hertfordshire EN11 9BU, GB
Inventors: CHEN, Qinghao; US
SCOTT, Jeremy; GB
KRSKA, Shane, W.; US
BAXTER, Carl; GB
STEWART, Gavin William; GB
TAN, Lushi; US
GIBB, Andrew; GB
MALIGRES, Peter, E.; US
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
62/235,06130.09.2015US
Title (EN) PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
(FR) PROCÉDÉ DE FABRICATION DE MODULATEURS ALLOSTÉRIQUES POSITIFS DU RÉCEPTEUR M1
Abstract:
(EN) This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.
(FR) La présente invention concerne de nouveaux procédés de préparation de composés tels que la 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-méthylpyridin-3-yl)méthyl]benzo[h]-quinazolin-4(3H)-one, de ses sels et de ses dérivés. Les composés synthétisés selon les procédés de l'invention sont utiles pour le traitement de la maladie d'Alzheimer et d'autres maladies (par exemple, une déficience cognitive, la schizophrénie, les troubles douloureux, et les troubles du sommeil) médiées par le récepteur muscarinique M1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)