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1. (WO2017057643) LEUKOCYTE INFILTRATION PROMOTER AND TUMOR IMMUNOACTIVATOR
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Pub. No.: WO/2017/057643 International Application No.: PCT/JP2016/078941
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
Chapter 2 Demand Filed: 17.03.2017
IPC:
A61K 45/00 (2006.01) ,A61K 31/683 (2006.01) ,A61K 31/685 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/04 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685
one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants: OSAKA UNIVERSITY[JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP
Inventors: TAKAKURA, Nobuyuki; JP
NAITO, Hisamichi; JP
TAKARA, Kazuhiro; JP
Agent: IWATANI, Ryo; JP
Priority Data:
2015-19120229.09.2015JP
Title (EN) LEUKOCYTE INFILTRATION PROMOTER AND TUMOR IMMUNOACTIVATOR
(FR) PROMOTEUR DE L'INFILTRATION DE LEUCOCYTES ET IMMUNO-ACTIVATEUR DES TUMEURS
(JA) 白血球浸潤促進剤および腫瘍免疫活性化剤
Abstract:
(EN) A substance that activates the lysophospholipid receptors is capable of normalizing abnormal blood vessels inside a tumor without affecting normal blood vessels, thereby causing or promoting the infiltration of leukocytes into some or all of the tumor region, and therefore is useful as a leukocyte infiltration promoter and a tumor immunoactivator. Furthermore, a substance that activates the lysophospholipid receptors can be used in combination with cancer immunotherapy to potentiate cancer immunotherapy, and therefore is useful as a cancer immunotherapy potentiator.
(FR) L'invention concerne une substance qui active les récepteurs aux lysophospholipides, capable de normaliser les vaisseaux sanguins anormaux au sein d'une tumeur sans affecter les vaisseaux sanguins normaux, permettant ainsi de susciter ou de favoriser l'infiltration de leucocytes dans certaines parties ou l'ensemble de la zone tumorale et de ce fait est utilisable comme promoteur de l'infiltration de leucocytes et comme immuno-activateur des tumeurs. En outre, une substance qui active les récepteurs aux lysophospholipides peut être utilisée en association avec une immunothérapie anticancéreuse pour potentialiser l'immunothérapie anticancéreuse, et de ce fait est utilisable comme agent de potentialisation d'une immunothérapie anticancéreuse.
(JA) リゾリン脂質受容体を活性化する物質は正常血管に影響を及ぼすことなく腫瘍内部の異常血管を正常化させ、その結果腫瘍領域の一部または全体への白血球の浸潤を生じさせるまたは促進させることができるので、白血球浸潤促進剤および腫瘍免疫活性化剤として有用である。さらに、リゾリン脂質受容体を活性化する物質は、がん免疫療法と組み合わせて使用することによりがん免疫療法を増強することができるので、がん免疫療法増強剤として有用である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)