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1. (WO2017057434) AQUEOUS PHARMACEUTICAL COMPOSITION

Pub. No.:    WO/2017/057434    International Application No.:    PCT/JP2016/078578
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Thu Sep 29 01:59:59 CEST 2016
IPC: A61K 31/382
A61K 31/5377
A61K 45/00
A61K 47/10
A61K 9/08
A61P 27/06
A61P 43/00
Applicants: SANTEN PHARMACEUTICAL CO., LTD.
参天製薬株式会社
Inventors: MORIMOTO, Takashi
森本 隆司
Title: AQUEOUS PHARMACEUTICAL COMPOSITION
Abstract:
Provided is an aqueous pharmaceutical composition that includes chlorobutanol and suppresses the decrease of pH with time and the breakdown of active ingredients. This aqueous pharmaceutical composition includes dorzolamide or a salt thereof and chlorobutanol. The pH of the composition is preferably 4.0 to 8.0. Additionally, the average pH reduction over 14 days from preservation at 60°C is preferably no larger than 0.046/day. The dorzolamide or salt thereof is preferably dorzolamide hydrochloride.