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|1. (WO2017057434) AQUEOUS PHARMACEUTICAL COMPOSITION|
|Applicants:||SANTEN PHARMACEUTICAL CO., LTD.
|Title:||AQUEOUS PHARMACEUTICAL COMPOSITION|
Provided is an aqueous pharmaceutical composition that includes chlorobutanol and suppresses the decrease of pH with time and the breakdown of active ingredients. This aqueous pharmaceutical composition includes dorzolamide or a salt thereof and chlorobutanol. The pH of the composition is preferably 4.0 to 8.0. Additionally, the average pH reduction over 14 days from preservation at 60°C is preferably no larger than 0.046/day. The dorzolamide or salt thereof is preferably dorzolamide hydrochloride.