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1. (WO2017056094) ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/056094 International Application No.: PCT/IL2016/051069
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
IPC:
A61K 35/76 (2015.01) ,C12N 7/04 (2006.01) ,G06F 19/10 (2011.01)
Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD.[IL/IL]; P.O. Box 39296 6139201 Tel-Aviv, IL
YEDA RESEARCH AND DEVELOPMENT CO. LTD.[IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot, IL
SYNVACCINE LTD.[IL/IL]; at RadBiomed 27 HaBarzel Street, MIgdalei Orr, Building A, 5th Floor Ramat HaChayal 6971039 Tel-Aviv, IL
Inventors: TULLER, Tamir; IL
GOZ, Eli; IL
ATAR, Shimshi; IL
ZUR, Hadas; IL
Agent: KESTEN, Dov; IL
EHRLICH, Gal; IL
WATERMAN, Hadassa; IL
MELNICK, Geoffrey, L.; IL
Priority Data:
62/234,82230.09.2015US
Title (EN) ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
(FR) VIRUS ATTÉNUÉS AYANT MUTÉ AU NIVEAU DE SITES À STRUCTURE D'ARN CONSERVÉE AU COURS DE L'ÉVOLUTION
Abstract: front page image
(EN) Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
(FR) La présente invention concerne des virus atténués et leurs procédés de conception. Dans un mode de réalisation, l'invention concerne une forme atténuée d'un virus virulent comprenant un ARN codant pour une protéine virale ou une séquence d'acide nucléique pouvant être transcrite en ledit ARN, l'énergie de repliement ou la structure de l'ARN étant modifiée au niveau des positions de structures d'ARN conservées au cours de l'évolution par rapport à celle dudit ARN codant pour ladite protéine virale dans le virus virulent de manière à obtenir l'atténuation du virus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)