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1. (WO2017055926) METHODS FOR ELECTROSPIN COATING AND LAMINATING OF ENDOLUMINAL PROSTHESES

Pub. No.:    WO/2017/055926    International Application No.:    PCT/IB2016/001529
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Tue Oct 04 01:59:59 CEST 2016
IPC: A61L 31/10
D04H 1/728
D01D 5/00
Applicants: XELTIS BV
Inventors: NAZ, Christophe Pierre Edouard
NANDAKUMAR, Anandkumar
SVANIDZE, Oleg
COX, Martijn Antonius Johannes
VOLPATO, Fabio, Zomer
Title: METHODS FOR ELECTROSPIN COATING AND LAMINATING OF ENDOLUMINAL PROSTHESES
Abstract:
Endoluminal and other as implantable prostheses are fabricated in electrospinning apparatus including a target and an applicator. A solution comprising a polymer and a solvent is directed to the target with a first electrical potential between the target and the applicator to produce a first set of fibers. The same or another solution is continued to be delivered through the applicator onto the target while applying a second electrical potential to produce a second set of fibers having a second solvent fraction, and the same or different solution may be delivered while applying a third potential difference to produce a laminated structure having at least three layers. By properly controlling the electrical potentials and solvent fractions, an adhesive layer can be formed to serve a glue or adhesive between the inner and outer layers, and a stent or other scaffold may be positioned between the inner and outer layers to form a covered stent or graft.