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1. (WO2017055860) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/055860    International Application No.:    PCT/GB2016/053042
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
IPC:
C07D 403/12 (2006.01), C07D 405/14 (2006.01), C07F 9/572 (2006.01), C07B 59/00 (2006.01), C07D 403/06 (2006.01), C07D 405/12 (2006.01), C07D 413/06 (2006.01), C07D 413/12 (2006.01), C07D 209/48 (2006.01), A61K 31/4035 (2006.01), A61P 35/00 (2006.01)
Applicants: ASTEX THERAPEUTICS LIMITED [GB/GB]; 436 Cambridge Science Park Milton Road Cambridge Cambridgeshire CB4 0QA (GB).
CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building 407 St. John Street London Greater London EC1V 4AD (GB)
Inventors: CHESSARI, Gianni; (GB).
HOWARD, Steven; (GB).
BUCK, Ildiko Maria; (GB).
CONS, Benjamin David; (GB).
JOHNSON, Christopher Norbert; (GB).
HOLVEY, Rhian Sara; (GB).
REES, David Charles; (GB).
ST. DENIS, Jeffrey David; (GB).
TAMANINI, Emiliano; (GB).
GOLDING, Bernard Thomas; (GB).
HARDCASTLE, Ian Robert; (GB).
CANO, Celine Florence; (GB).
MILLER, Duncan Charles; (GB).
CULLY, Sarah; (GB).
NOBLE, Martin Edward Mäntylä; (GB).
GRIFFIN, Roger John; .
OSBORNE, James Daniel; (GB).
PEACH, Joanne; (GB).
LEWIS, Arwel; (GB).
HIRST, Kim Louise; (GB).
WHITTAKER, Benjamin Paul; (GB).
WATSON, David Wyn; (GB).
MITCHELL, Dale Robert; (GB)
Agent: COOKE, Richard; (GB)
Priority Data:
1517217.4 29.09.2015 GB
Title (EN) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY
(FR) INHIBITEURS ISOINDOLINONE DE L'INTERACTION MDM2-P53 AYANT UNE ACTIVITÉ ANTICANCÉREUSE
Abstract: front page image
(EN)The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
(FR)L'invention concerne un composé de formule (I) : (I) ou un tautomère ou un solvate ou un sel pharmaceutiquement acceptable de celui-ci, les divers substituants étant tels que définis dans les revendications. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule (I), des procédés de fabrication des composés et les utilisations médicales des composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)