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1. (WO2017055423) OLIGONUCLEOTIDE CONJUGATION PROCESS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/055423    International Application No.:    PCT/EP2016/073224
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
IPC:
A61K 47/54, A61K 47/55
Applicants: ROCHE INNOVATION CENTER COPENHAGEN A/S [DK/DK]; Fremtidsvej 3 2970 Hørsholm (DK)
Inventors: HANSEN, Dennis Jul; (DK).
ROSENBOHM, Christoph; (DK).
MELDGAARD, Michael; (DK)
Agent: TURNER, Mark; (CH)
Priority Data:
15188120.8 02.10.2015 EP
Title (EN) OLIGONUCLEOTIDE CONJUGATION PROCESS
(FR) PROCÉDÉ DE CONJUGAISON D'OLIGONUCLÉOTIDES
Abstract: front page image
(EN)The present invention relates to the field of oligonucleotide conjugates and to methods of synthesis thereof. In the present method a low-water content solvent environment allows a more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the conjugation reaction speed.
(FR)La présente invention concerne le domaine des conjugués d'oligonucléotides et des procédés de synthèse de ceux-ci. Dans le procédé de la présente invention un environnement de solvant à faible teneur en eau permet d'obtenir une conjugaison plus efficace, de réduire la quantité de fragment de conjugué nécessaire et d'augmenter la vitesse de réaction de conjugaison.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)