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1. (WO2017055398) BISPECIFIC ANTIBODIES SPECIFIC FOR A COSTIMULATORY TNF RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/055398    International Application No.:    PCT/EP2016/073185
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
IPC:
C07K 16/28 (2006.01), C07K 16/40 (2006.01), C07K 16/30 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department Little Falls, New Jersey 07424 (US) (US only)
Inventors: AMANN, Maria; (CH).
BRUENKER, Peter; (CH).
CLAUS, Christina; (CH).
FERRARA KOLLER, Claudia; (CH).
GRAU-RICHARDS, Sandra; (CH).
HOSSE, Ralf; (CH).
KLEIN, Christian; (CH).
LEVITSKI, Viktor; (CH).
UMAÑA, Pablo; (CH)
Agent: KLOSTERMEYER-RAUBER, Doerte; (CH)
Priority Data:
15188095.2 02.10.2015 EP
16170363.2 19.05.2016 EP
Title (EN) BISPECIFIC ANTIBODIES SPECIFIC FOR A COSTIMULATORY TNF RECEPTOR
(FR) ANTICORPS BISPÉCIFIQUES SPÉCIFIQUES D'UN RÉCEPTEUR DE CO-STIMULATION DU TNF
Abstract: front page image
(EN)The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
(FR)L'invention concerne de nouvelles molécules bispécifiques de liaison à un antigène, comprenant (a) au moins un fragment capable de se lier de manière spécifique à un antigène de cellule cible, (b) au moins un fragment capable de se lier de manière spécifique à un membre de la famille du récepteur de costimulation du TNF, et (c) un domaine Fc composé d'une première et d'une seconde sous-unités capables d'association stable. L'invention concerne en outre des procédés de production de ces molécules et des procédés d'utilisation associés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)