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1. (WO2017055397) METABOLOMIC SIGNATURE OF DIAGNOSIS AND DISEASE PROGRESSION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
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Pub. No.: WO/2017/055397 International Application No.: PCT/EP2016/073183
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
IPC:
G01N 33/68 (2006.01) ,G01N 33/92 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92
involving lipids, e.g. cholesterol
Applicants:
ONE WAY LIVER, S.L. [ES/ES]; Parque Tecnológico de Bizkaia Edificio 502, Planta 0 48160 Derio-Bizkaia, ES
VIRGINIA COMMONWEALTH UNIVERSITY; 800 E Leigh St., Suite 3000 Richmond, 23298, US
Inventors:
ALONSO SÁNCHEZ, Cristina; ES
MARTÍNEZ ARRANZ, Ibon; ES
MATO DE LA PAZ, José María; ES
SANYAL, Arun J; US
Agent:
VÁZQUEZ VÁZQUEZ, Irene; ES
Priority Data:
15382477.630.09.2015EP
Title (EN) METABOLOMIC SIGNATURE OF DIAGNOSIS AND DISEASE PROGRESSION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
(FR) SIGNATURE MÉTABOLOMIQUE DE DIAGNOSTIC ET DE PROGRESSION DE MALADIE DE STÉATOSE HÉPATIQUE NON ALCOOLIQUE (NAFLD)
Abstract:
(EN) The present invention is directed to a diagnostic method for non-alcoholic fatty liver disease (NAFLD) and to a method for monitoring the progression of the disease based on the determination of the levels of different metabolites. The invention also provides a method for determining the efficacy of an NAFLD therapy and a method for identification of compounds suitable for the treatment of NAFLD.
(FR) La présente invention concerne un procédé de diagnostic de stéatose hépatique non-alcoolique (NAFLD) et un procédé pour surveiller la progression de la maladie sur la base de la détermination des niveaux de différents métabolites. L'invention concerne également un procédé pour déterminer l'efficacité d'une thérapie de NAFLD et un procédé d'identification de composés appropriés pour le traitement de NAFLD.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)