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1. (WO2017055391) BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES BINDING MESOTHELIN AND CD3
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Pub. No.: WO/2017/055391 International Application No.: PCT/EP2016/073173
Publication Date: 06.04.2017 International Filing Date: 29.09.2016
IPC:
C07K 16/30 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/46 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road 8th Floor, Suite 8 - Legal Department Little Falls, New Jersey 07424, US (US)
Inventors:
BACAC, Marina; CH
FAUTI, Tanja; CH
FREIMOSER-GRUNDSCHOBER, Anne; CH
IMHOF-JUNG, Sabine; DE
KLEIN, Christian; CH
KLOSTERMANN, Stefan; DE
MOLHOJ, Michael; DE
NIEDERFELLNER, Gerhard; DE
REGULA, Joerg Thomas; DE
SCHAEFER, Wolfgang; DE
UMAÑA, Pablo; CH
Agent:
CUENI, Leah; CH
Priority Data:
15188038.202.10.2015EP
Title (EN) BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES BINDING MESOTHELIN AND CD3
(FR) MOLÉCULES DE LIAISON À L'ANTIGÈNE ACTIVANT LES CELLULES T BISPÉCIFIQUES LIANT LA MÉSOTHÉLINE ET CD3
Abstract:
(EN) The present disclosure generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present disclosure relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The disclosure further relates to methods for producing the bispecific antigen binding molecules of the disclosure, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
(FR) La présente invention concerne de manière générale de nouvelles molécules bispécifiques de liaison à l'antigène destinées à activer les lymphocytes T et à les rediriger vers des cellules cibles spécifiques. De plus, la présente invention concerne des polynucléotides codant pour ces molécules bispécifiques de liaison à l'antigène, ainsi que des vecteurs et des cellules hôtes comprenant ces polynucléotides. L'invention concerne par ailleurs des procédés de production des molécules bispécifiques de liaison à l'antigène de l'invention, et des procédés d'utilisation de ces molécules bispécifiques de liaison à l'antigène dans le traitement de maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)