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|1. (WO2017055337) AQUEOUS COMPOSITION OF APOMORPHINE FOR SUBCUTANEOUS ADMINISTRATION|
|Applicants:||EVER NEURO PHARMA GMBH
MEIER, Dieter Horst
|Title:||AQUEOUS COMPOSITION OF APOMORPHINE FOR SUBCUTANEOUS ADMINISTRATION|
The present invention relates to an aqueous composition comprising apomorphine or a pharmaceutically acceptable salt or solvate thereof, reduced glutathione (GSH) or a pharmaceutically acceptable salt thereof, and ascorbic acid or a pharmaceutically acceptable salt or derivative thereof, wherein the composition has a pH of about 3 to about 7.4. The aqueous composition according to the invention exhibits superior tolerability and an improved side effect profile, particularly a reduced occurrence of skin nodule formation and panniculitis, when administered subcutaneously. The invention further relates to the composition for use as a medicament, particularly for the treatment of Parkinson's disease.