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1. (WO2017055337) AQUEOUS COMPOSITION OF APOMORPHINE FOR SUBCUTANEOUS ADMINISTRATION

Pub. No.:    WO/2017/055337    International Application No.:    PCT/EP2016/073086
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Thu Sep 29 01:59:59 CEST 2016
IPC: A61K 31/473
A61P 25/00
A61P 25/16
A61P 25/28
A61P 25/18
A61P 15/00
A61P 15/10
A61K 9/00
A61K 47/12
A61K 47/20
Applicants: EVER NEURO PHARMA GMBH
Inventors: SCHNAIT, Heinz
TÖLGYESI, Zoltán
SCHMIDT, Sabine
HARTWIG, Kerstin
MEIER, Dieter Horst
SELIGER, Christian
Title: AQUEOUS COMPOSITION OF APOMORPHINE FOR SUBCUTANEOUS ADMINISTRATION
Abstract:
The present invention relates to an aqueous composition comprising apomorphine or a pharmaceutically acceptable salt or solvate thereof, reduced glutathione (GSH) or a pharmaceutically acceptable salt thereof, and ascorbic acid or a pharmaceutically acceptable salt or derivative thereof, wherein the composition has a pH of about 3 to about 7.4. The aqueous composition according to the invention exhibits superior tolerability and an improved side effect profile, particularly a reduced occurrence of skin nodule formation and panniculitis, when administered subcutaneously. The invention further relates to the composition for use as a medicament, particularly for the treatment of Parkinson's disease.