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1. WO2017055325 - METHODS FOR QUANTIFYING THE POPULATION OF NK CELLS IN A TISSUE SAMPLE

Publication Number WO/2017/055325
Publication Date 06.04.2017
International Application No. PCT/EP2016/073057
International Filing Date 28.09.2016
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6881
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6881for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • UNIVERSITÉ PARIS DIDEROT - PARIS 7 [FR]/[FR]
  • UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) [FR]/[FR]
  • UNIVERSITÉ PARIS DESCARTES [FR]/[FR]
  • LIGUE NATIONALE CONTRE LE CANCER [FR]/[FR]
  • ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) [FR]/[FR]
Inventors
  • FRIDMAN, Wolf Herman
  • DE REYNIES, Aurélien
  • BECHT, Etienne
Agents
  • COLLIN, Matthieu
Priority Data
15306523.029.09.2015EP
16305878.712.07.2016EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR QUANTIFYING THE POPULATION OF NK CELLS IN A TISSUE SAMPLE
(FR) PROCÉDÉS DE QUANTIFICATION DE LA POPULATION DE CELLULES NK DANS UN PRÉLÈVEMENT DE TISSU
Abstract
(EN)
The present invention relates to methods for quantifying the population of NK cells in a tissue sample. In particular, the present invention relates to a method for quantifying the population of NK cells in a tissue sample obtained from a subject comprising determining the expression level of at least one gene selected from the group consisting of KIR2DL1, KIR2DL3, NCR1, KIR3DL1, KIR3DS1, KIR3DL2, SH2D1B, CD160, GENE 2 and KIR2DL4.
(FR)
La présente invention concerne des procédés de quantification de la population de cellules NK dans un prélèvement de tissu. En particulier, la présente invention concerne un procédé de quantification de la population de cellules NK dans un prélèvement de tissu obtenu auprès d’un sujet comprenant la détermination du niveau d’expression d’au moins un gène sélectionné dans le groupe constitué de KIR2DL1, KIR2DL3, NCR1, KIR3DL1, KIR3DS1, KIR3DL2, SH2D1B, CD160, GENE 2 et KIR2DL4.
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