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1. (WO2017055320) METHODS FOR QUANTIFYING THE POPULATION OF CYTOTOXIC LYMPHOCYTES IN A TISSUE SAMPLE

Pub. No.:    WO/2017/055320    International Application No.:    PCT/EP2016/073048
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Thu Sep 29 01:59:59 CEST 2016
IPC: C12Q 1/68
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
UNIVERSITÉ PARIS DIDEROT - PARIS 7
UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6)
UNIVERSITÉ PARIS DESCARTES
LIGUE NATIONALE CONTRE LE CANCER
ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
Inventors: FRIDMAN, Wolf Herman
DE REYNIES, Aurélien
BECHT, Etienne
Title: METHODS FOR QUANTIFYING THE POPULATION OF CYTOTOXIC LYMPHOCYTES IN A TISSUE SAMPLE
Abstract:
The present invention relates to methods for quantifying the population of cytotoxic lymphocytes in a tissue sample. In particular, the present invention relates to a method for quantifying the population of cytotoxic lymphocytes in a tissue sample obtained from a subject comprising determining the expression level of at least one gene selected from the group consisting of KLRC4-KLRK1 /// KLRK1, CD8A, KLRD1, GNLY, EOMES, KLRC3, KLRC4, FGFBP2 and KLRC1 /// KLRC2.