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1. (WO2017055318) CD33XCD3 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

Pub. No.:    WO/2017/055318    International Application No.:    PCT/EP2016/073046
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Thu Sep 29 01:59:59 CEST 2016
IPC: C07K 16/28
C07K 16/46
A61P 35/02
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: KLEIN, Christian
SCHAEFER, Wolfgang
KLOSTERMANN, Stefan
IMHOF-JUNG, Sabine
MOLHOJ, Michael
REGULA, Joerg Thomas
FAUTI, Tanja
DUMONTET, Charles
UMANA, Pablo
BACAC, Marina
FREIMOSER-GRUNDSCHOBER, Anne
Title: CD33XCD3 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
Abstract:
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.