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1. (WO2017055235) IMPROVED MODULAR ANTIGEN TRANSPORTATION MOLECULES AND USES THEROF IN ANIMALS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/055235 International Application No.: PCT/EP2016/072898
Publication Date: 06.04.2017 International Filing Date: 27.09.2016
IPC:
A61K 39/35 (2006.01) ,A61K 39/385 (2006.01) ,C12N 15/62 (2006.01) ,C07K 17/06 (2006.01) ,C07K 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
35
Allergens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
02
Peptides being immobilised on, or in, an organic carrier
06
attached to the carrier via a bridging agent
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
Applicants: BOEHRINGER INGELHEIM VETMEDICA GMBH[DE/DE]; Binger Str. 173 55216 Ingelheim Am Rhein, DE
Inventors: ROSE, Horst; DE
REICHE, Dania-Birte; DE
TAMMEN, Harald; DE
Agent: SIMON, Elke; DE
BAUER, Mr Oliver; DE
Priority Data:
15187810.530.09.2015EP
Title (EN) IMPROVED MODULAR ANTIGEN TRANSPORTATION MOLECULES AND USES THEROF IN ANIMALS
(FR) MOLÉCULES DE TRANSPORT D’ANTIGÈNE MODULAIRE AMÉLIORÉES ET LEURS UTILISATIONS CHEZ DES ANIMAUX
Abstract:
(EN) The present invention relates to (isolated) recombinant proteins, also referred to as improved MAT (iMAT) molecules, comprising at least one translocation module, at least one targeting module and at least one antigen module, wherein at least one cysteine residue is substituted with a different amino acid residue. Such iMAT molecules are useful specifically as vaccines, e.g. for therapy and/or prevention of allergies and/or infectious diseases and/or prevention of transmission of infectious diseases in animals, more preferably ruminants, pigs, dogs and/or cats, but excluding equines. The present invention further relates to nucleic acids encoding such iMAT molecules, corresponding vectors and primary cells or cell lines.
(FR) La présente invention concerne des protéines recombinantes (isolées), également appelées molécules MAT améliorées (iMAT), comprenant au moins un module de translocation, au moins un module de ciblage et au moins un module d'antigène, au moins un résidu de cystéine étant substitué par un résidu d'acide aminé différent. De telles molécules iMAT sont particulièrement utiles en tant que vaccins, par exemple pour le traitement et/ou la prévention d'allergies et/ou de maladies infectieuses et/ou la prévention de la transmission de maladies infectieuses chez les animaux, de préférence les ruminants, les porcs, les chiens et/ou les chats, mais en excluant les équidés. La présente invention concerne en outre des acides nucléiques codant pour de telles molécules iMAT, des vecteurs et des cellules primaires ou des lignées cellulaires correspondants.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)