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|1. (WO2017054141) HER2 LINEAR EPITOPE NEUTRALIZING ACTIVITY MONOCLONAL ANTIBODY AND USE THEREOF|
|Applicants:||ABMAX BIOTECHNOLOGY CO., LTD.
|Title:||HER2 LINEAR EPITOPE NEUTRALIZING ACTIVITY MONOCLONAL ANTIBODY AND USE THEREOF|
Provided are an HER2 linear epitope neutralizing activity monoclonal antibody and a preparation method thereof. The method comprises coupling a polypeptide containing amino acids at positions 374-398 of the HER2 and a carrier protein, and immunizing mice to prepare the monoclonal antibody secreting a plurality of hybridoma cells, same being capable of specifically recognizing the HER2 of the cell surface of breast cancer, and having a neutralizing activity. The polypeptide can be used to prepare the HER2 monoclonal antibody and therapeutic drugs for treating diseases targeted at HER2; and the binding affinity of the monoclonal antibody and the HER2 is between 1-4nM, and can be used in combination with Trastuzumab or Pertuzumab.