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Pub. No.: WO/2017/054058 International Application No.: PCT/AU2016/050927
Publication Date: 06.04.2017 International Filing Date: 30.09.2016
Chapter 2 Demand Filed: 26.07.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants: IMMUNEXPRESS PTY LTD[AU/AU]; 6 Leonard Street Boonah, Queensland 4310, AU
Inventors: BRANDON, Richard Bruce; AU
FOX, Brian Andrew; US
MCHUGH, Leo Charles; US
SAMPSON, Dayle Lorand; US
Agent: DAVIES COLLISON CAVE PTY LTD; 10/301 Coronation Drive Milton, Queensland 4064, AU
Priority Data:
201590398630.09.2015AU
Title (EN) PATHOGEN BIOMARKERS AND USES THEREFOR
(FR) BIOMARQUEURS PATHOGÈNES ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.
(FR) L'invention concerne des compositions, des procédés et un appareil pour le diagnostic et/ou la surveillance d'une inflammation systémique associée à un virus par mesure de la réponse immunitaire d'un hôte. L'invention peut être utilisée pour le diagnostic comprenant le diagnostic précoce, la surveillance, la prise de décisions thérapeutiques, ou la gestion de sujets suspectés de souffrir d'une inflammation systémique associée à une infection. Plus particulièrement, la présente invention concerne des biomarqueurs de protéines et d'ARN du sang périphérique qui sont utiles pour différencier spécifiquement la réponse immunitaire systémique de l'hôte à des virus de la réponse immunitaire de l'hôte à d'autres causes d'inflammation systémique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)