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1. WO2017053315 - GENETICALLY MODIFIED ANIMALS HAVING INCREASED HEAT TOLERANCE

Publication Number WO/2017/053315
Publication Date 30.03.2017
International Application No. PCT/US2016/052693
International Filing Date 20.09.2016
IPC
A01K 67/027 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
C07K 14/72 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
CPC
A01K 2217/072
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
07Animals genetically altered by homologous recombination
072maintaining or altering function, i.e. knock in
A01K 2227/101
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
101Bovine
A01K 2267/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
02Animal zootechnically ameliorated
A01K 67/0275
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
C07K 14/715
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
C12N 15/907
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90Stable introduction of foreign DNA into chromosome
902using homologous recombination
907in mammalian cells
Applicants
  • RECOMBINETICS, INC. [US]/[US]
Inventors
  • SONSTEGARD, Tad, S.
  • CARLSON, Daniel, F.
  • FAHRENKRUG, Scott, C.
Agents
  • HERBERT, Curtis, B.
  • FOSSEN, Kayla, J.
  • DARDI, Peter, S.
Priority Data
62/221,44421.09.2015US
62/327,11525.04.2016US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GENETICALLY MODIFIED ANIMALS HAVING INCREASED HEAT TOLERANCE
(FR) ANIMAUX GÉNÉTIQUEMENT MODIFIÉS AYANT UNE MEILLEURE TOLÉRANCE À LA CHALEUR
Abstract
(EN) Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin receptor (PRLR) gene. When expressed, the livestock animals produce a PRLR that is missing up to the terminal 148 amino acid (aa) residues of the protein all ranges and values within the explicitly stated range are contemplated: e.g., from 148 to 69. Animals expressing SLICK have superior thermoregulatory ability compared to non-slick animals and experience a less drastic depression in milk yield during the summer.
(FR) L'invention concerne des animaux de bétail à génome modifié et des procédés permettant de les fournir avec l'expression du phénotype SLICK. Les animaux de l'invention expriment un allèle tronqué pour le gène du récepteur de la prolactine (PRLR). Lorsqu'il est exprimé, les animaux de bétail produisent un PRLR qui manque jusqu'aux 148 acides aminés (aa) résidus terminaux de la protéine, toutes les plages et valeurs dans la plage spécifiée explicitement sont envisagées : par exemple, de 148 à 69. Des animaux exprimant SLICK ont une meilleure capacité de thermorégulation par rapport aux animaux sans SLICK et subissent une réduction du rendement laitier moins drastique pendant l'été.
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