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Pub. No.:    WO/2017/049983    International Application No.:    PCT/CN2016/088091
Publication Date: 30.03.2017 International Filing Date: 01.07.2016
C07D 493/10 (2006.01), A61K 31/35 (2006.01), A61K 31/381 (2006.01), A61K 31/427 (2006.01), A61K 31/4436 (2006.01), A61P 3/10 (2006.01), A61P 9/10 (2006.01), A61P 3/04 (2006.01)
Applicants: SUZHOU LIXIN PHARMACEUTICAL CO., LTD [CN/CN]; No. 21,Tangxi Road, New District Suzhou, Jiangsu 215000 (CN).
XU, Xuenong [CN/CN]; (CN)
Inventors: XU, Xuenong; (CN).
BAO, Zhijian; (CN).
WANG, Zhe; (CN).
ZHANG, Wenjian; (CN).
SU, Jian; (CN).
GU, Xinyu; (CN).
XUE, Jia; (CN).
XIE, Lingling; (CN)
Agent: SUZHOU WISTONG INTELLECTUAL PROPERTY AGENCY(COMMON PARTNERSHIP); Room 804, Building 5 Intellectual property concentrated area Xuesen Road 9, Science& Technology Town, New District Suzhou, Jiangsu 215163 (CN)
Priority Data:
201510618067.6 25.09.2015 CN
(ZH) 库潘尼西的制备方法
Abstract: front page image
(EN)The invention discloses a preparation method of copanlisib (BAY 80-6946), taking a known compound of a 2-amino-3-methoxy-4-(3-morpholin-4-ylpropoxy)benzonitrile as a starting material, and performing thereon heterocyclization, cyclic condensation, halogenated amination, amidization, or other unit processes. The preparation method requires an easily accessible material and simple technology, and is cost-effective, environmental friendly, and suitable for industrial production.
(FR)L'invention concerne un procédé de préparation de copanlisib (BAY 80-6946), consistant à prendre un composé connu d'un 2-amino-3-méthoxy-4-(3-morpholin-4-ylpropoxy)benzonitrile en tant que matériau de départ, et à mettre en oeuvre sur celui-ci une hétérocyclisation, une condensation cyclique, une amination halogénée, une amidisation ou d'autres procédés unitaires. Le procédé de préparation nécessite un matériau facilement accessible et une technologie simple, et est rentable, respectueux de l'environnement, et approprié pour une production industrielle.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)