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1. (WO2017041403) FLUORESCENT PROBE SUBSTRATE FOR DETERMINING ACTIVITY OF DIPEPTIDYL PEPTIDASE IV, AND USE THEREOF
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Pub. No.: WO/2017/041403 International Application No.: PCT/CN2016/000476
Publication Date: 16.03.2017 International Filing Date: 23.08.2016
IPC:
C07K 5/062 (2006.01) ,C12Q 1/37 (2006.01)
[IPC code unknown for C07K 5/062][IPC code unknown for C12Q 1/37]
Applicants:
中国科学院大连化学物理研究所 DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国辽宁省大连市 沙河口区中山路457号 No.457 Zhongshan Road, Shahekou District Dalian, Liaoning 116023, CN
Inventors:
杨凌 YANG, Ling; CN
邹立伟 ZOU, Liwei; CN
葛广波 GE, Guangbo; CN
王平 WANG, Ping; CN
Agent:
沈阳晨创科技专利代理有限责任公司 SHENYANG CHENCHUANG TECHNICAL PATENT AGENT LTD; CN
Priority Data:
201510572172.010.09.2015CN
Title (EN) FLUORESCENT PROBE SUBSTRATE FOR DETERMINING ACTIVITY OF DIPEPTIDYL PEPTIDASE IV, AND USE THEREOF
(FR) SUBSTRAT DE SONDE FLUORESCENTE POUR DÉTERMINER L'ACTIVITÉ DE LA DIPEPTIDYL-PEPTIDASE IV ET UTILISATION DE CE SUBSTRAT
(ZH) 一种测定二肽基肽酶IV活性的荧光探针底物及其应用
Abstract:
(EN) The present invention provides a fluorescent probe substrate for determining an activity of dipeptidyl peptidase IV (DPP-IV) and a use thereof. The probe substrate is a C-4 amide derivative of naphthalimides, GPAN, and can be used to determine an enzyme activity of DPP-IV in different biological systems.
(FR) La présente invention concerne un substrat de sonde fluorescente pour déterminer une activité de la dipeptidyl-peptidase IV (DPP-IV) et une utilisation de ce substrat. Ledit substrat de sonde est un dérivé amide C-4 de naphtalimides, GPAN, et peut être utilisé pour déterminer une activité enzymatique de la DPP-IV dans différents systèmes biologiques.
(ZH) 本发明提供了一种二肽基肽酶IV的特异性荧光探针底物及其应用,该探针底物为萘酰亚胺的C-4酰胺衍生物GPAN,可用于测定不同生物体系中DPP-IV的酶活。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)