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1. (WO2017041228) METHOD FOR PREPARING HEXAHYDROFUROFURANOL DERIVATIVE, INTERMEDIATE THEREOF AND PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/041228 International Application No.: PCT/CN2015/089162
Publication Date: 16.03.2017 International Filing Date: 08.09.2015
IPC:
C07D 493/04 (2006.01) ,C07D 407/04 (2006.01) ,C07D 307/32 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
26
having one double bond between ring members or between a ring member and a non-ring member
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32
Oxygen atoms
Applicants:
浙江九洲药业股份有限公司 ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD [CN/CN]; 中国浙江省台州市 椒江区外沙路99号 99 Waisha Road, Jiaojiang District Taizhou, Zhejiang 318000, CN
Inventors:
朱国良 ZHU, Guoliang; CN
张斌 ZHANG, Bin; CN
陈小华 CHEN, Xiaohua; CN
李杰平 LI, Jieping; CN
钱灵锋 QIAN, Lingfeng; CN
徐立 XU, Li; CN
杜小华 DU, Xiaohua; CN
何大伟 HE, Dawei; CN
Priority Data:
Title (EN) METHOD FOR PREPARING HEXAHYDROFUROFURANOL DERIVATIVE, INTERMEDIATE THEREOF AND PREPARATION METHOD THEREOF
(FR) PROCÉDÉ DE PRÉPARATION D'UN DÉRIVÉ D'HEXAHYDROFUROFURANOL, INTERMÉDIAIRE CORRESPONDANT ET PROCÉDÉ DE PRÉPARATION CORRESPONDANT
(ZH) 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
Abstract:
(EN) The present invention relates to the field of pharmaceutical synthesis, in particular to a method for preparing a hexahydrofurofuranol derivative, an intermediate thereof and a preparation method thereof. The preparation method uses a compound of formula A1 as an initial material, wherein R1 and R2 are the same or different alkyls, which differs from the initial material reported by the present patent documents, and the specific preparation method is different from that of the prior art patent documents; however, the preparation method can achieve the industrial production of a Darunavir key intermediate, (3R,3aS,6aR)-hexahydrofuro[2,3-b]-3-alcohol.
(FR) La présente invention concerne le domaine de la synthèse pharmaceutique, en particulier un procédé de préparation d'un dérivé d'hexahydrofurofuranol, un intermédiaire correspondant et un procédé de préparation correspondant. Le procédé de préparation utilise un composé de formule A1 en tant que matériau initial, R1 et R2 représentant des alkyles identiques ou différents, qui est différent du matériau initial rapporté par les documents de brevets actuels, et le procédé de préparation spécifique est différent de celui des documents de brevets de l'état antérieur de la technique ; cependant, le procédé de préparation permet d'obtenir la production industrielle d'un intermédiaire clé du Darunavir, le (3R,3aS,6aR)-hexahydrofuro[2,3-b]-3-alcool.
(ZH) 本发明涉及医药合成领域,具体涉及六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法。该制备方法以式A1化合物为起始原料,其中,R1,R2相同或不同的为烷基。这与现有专利文献中报导的起始原料不同,具体的制备方法也与现有专利文献不同,但该制备方法能产业化地生产达芦那韦关键中间体(3R,3aS,6aR)-六氢呋喃并[2,3-b]-3-醇。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)