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1. (WO2017041180) HETEROCYCLIC TEC-FAMILY KINASE INHIBITORS

Pub. No.:    WO/2017/041180    International Application No.:    PCT/CA2016/051068
Publication Date: Fri Mar 17 00:59:59 CET 2017 International Filing Date: Sat Sep 10 01:59:59 CEST 2016
IPC: C07D 487/04
A61K 31/519
A61K 49/00
A61K 51/04
A61P 31/18
A61P 25/00
Applicants: PHARMASCIENCE INC.
Inventors: LAURENT, Alain
ROSE, Yannick
MORRIS, Stephen J.
Title: HETEROCYCLIC TEC-FAMILY KINASE INHIBITORS
Abstract:
Compounds having the Formula (I), and enantiomers, diastereomers, pharmaceutically acceptable salts, solvates and solvates of salts thereof, (Formula I)) are useful as kinase inhibitors or modulators, including BTK modulation or inhibition, wherein X1, X2, m, m', E and R1 are as defined herein.