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1. (WO2017041143) CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Pub. No.:    WO/2017/041143    International Application No.:    PCT/AU2016/050851
Publication Date: Fri Mar 17 00:59:59 CET 2017 International Filing Date: Sun Sep 11 01:59:59 CEST 2016
IPC: C12N 15/62
C12N 5/0781
C12N 5/0783
C07K 19/00
A61K 35/17
A61P 35/00
Applicants: CARINA BIOTECH PTY LTD
Inventors: COOMBS, Justin, Taylor
BARRY, Simon, Charles
SADLON, Timothy, John
Title: CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
Abstract:
The present invention relates to chimeric antigen receptors (CARs) directed to cells expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumours expressing a dysfunctional or non- functional P2X purinoceptor 7 receptor and methods of treating and preventing cancer is a subject.